This extra genetic material is responsible for the characteristic features and developmental problems of Down syndrome.
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These cell division abnormalities result in an extra partial or full chromosome 21. One chromosome in each pair comes from your father, the other from your mother.ĭown syndrome results when abnormal cell division involving chromosome 21 occurs. Human cells normally contain 23 pairs of chromosomes. Request an Appointment at Mayo Clinic Causes However, if you have any questions regarding your pregnancy or your child's growth and development, talk with your doctor. When to see a doctorĬhildren with Down syndrome usually are diagnosed before or at birth. Language is delayed, and both short and long-term memory is affected. Most children with Down syndrome have mild to moderate cognitive impairment. Infants with Down syndrome may be average size, but typically they grow slowly and remain shorter than other children the same age. Tiny white spots on the colored part (iris) of the eye called Brushfield's spots.Relatively short fingers and small hands and feet.Broad, short hands with a single crease in the palm.Upward slanting eye lids (palpebral fissures).Though not all people with Down syndrome have the same features, some of the more common features include:
Some people are healthy while others have significant health problems such as serious heart defects.Ĭhildren and adults with Down syndrome have distinct facial features. Retrieved 28 October 2016.Each person with Down syndrome is an individual - intellectual and developmental problems may be mild, moderate or severe. ^ "British single certifications – Status Quo – Down Down".Australian Chart Book 1970–1992 (illustrated ed.). ^ " Status Quo – Down, Down" (in Dutch).^ " Status Quo – Down, Down" (in French).^ " Status Quo – Down, Down" (in German).^ "Status Quo Concert Setlist at Roundhouse, London on Octosetlist.fm".^ "Status Quo perform Down, Down for Coles".
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^ "Coles Mince is Staying Down with Status Quo - Coles TV Ad".Archived from the original on 7 April 2014. "Status Quo rock for Coles commercial | B&T". ^ "Back In Quo Country: Expanded Edition – Cherry Red Records"."John Peel's comments on playing 'Down Down', in The Guardian". ^ "Norfolk's Status Quo top 10 songs"."Status Quo Facts: 8 Essential Things You Need To Know". ^ Shipments figures based on certification alone. It was featured in the ninety-minute launch performance of the album at London's Roundhouse on 22 October and recorded and broadcast live by BBC Radio 2 as part of their In Concert series. The song was reprised, in 2014, for the band's thirty-first studio album Aquostic (Stripped Bare). This was released on television and YouTube, the most notable of which depicted a mince rally. The chorus chants, "down, down, prices are down". In July 2012, Status Quo reworked the lyrics to create a three-minute promotional song for the Australian supermarket chain Coles. In 1986 co-writer Bob Young recorded a country style version of the song to open his solo album In Quo Country. Towards the end of his life, DJ John Peel was known for playing "Down Down" as part of his eclectic DJ sets. Originally it was titled "Get Down", but this was changed before release, possibly to avoid confusion with the Gilbert O'Sullivan song of the same name.
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